06 Gluconeogenesis
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- costs energy
- secrete glucose into blood
- other sources of carbon and molecules can be converted to glucose
- gluconeogenesis costs ATP
- cell only wants to go in either TCA or gluconeogenesis
- acetyl coa indicator of metabolic activity
- ATP inhibits enzymes of TCA, acetyl coa levels go up
- acetyl coa allosterically activates pyruvate carboxylase
PEPCK
- carboxylase adds COOH
- PEPCK
- 1st step occur in mito
- rest in cytosol
- any carboxylase enzyme using CO2 and ATP needs biotin
- high levels of ATP drive pyruvate into gluconeogenesis (can't) and thus into lactate
F16BP
G6Pase
- Glucose 6 phosphatse in ER
Hormonal Control
- only odd chain FA can be converted to glucose
- glycerol from triglycerides
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